Vesicles: Symptoms | Causes | Treatment


What are vesicles?

Vesicles are small, fluid-filled sacs that can appear on your skin. The fluid inside these sacs may be clear, white, yellow, or mixed with blood.

Vesicles are also sometimes referred to as blisters or bullae, though there are slight size differences among the three. Vesicles are typically about 5 to 10 millimeters in diameter. If the sacs become larger than that, they’re classified as blisters. If they have a diameter of at least half a centimeter, they’re known as bullae.

What causes vesicles?

Vesicles develop when fluid becomes trapped under the epidermis, the top layer of your skin. A number of different health conditions can cause them. Some of these conditions are minor and don’t require medical attention. Others are more serious and can signal a complicated medical issue that needs ongoing treatment.

Minor causes of vesicles include:

  • allergic reactions that cause skin irritation
  • dermatitis or eczema
  • contact dermatitis, such as from poison ivy or poison oak
  • cold sores

You should see a doctor if your vesicles are a result of:

  • autoimmune disorders, such as bullous pemphigoid
  • chickenpox or shingles
  • skin diseases that cause blistering, such as porphyria cutanea tarda
  • impetigo, a skin condition caused by infection with strep or staph bacteria
  • herpes

What are the symptoms?

Vesicles are often easy to recognize. Most develop on the surface of the skin and cause it to swell with fluid. The skin around a vesicle keeps the fluid contained.

Vesicles tend to rupture easily and release their fluid onto the skin. When the fluid dries, it may turn yellow or crusty.

Conditions that produce symptoms similar to vesicles can include:

  • boils
  • burns
  • frostbite
  • staph infections
  • skin nodules
  • neurofibromas, or tumors that develop on the nerves
  • infected hair follicles

When a rash appears in the same place as multiple vesicles, it’s known as a vesicular rash. Heat rashes are one type of vesicular rash, occurring mainly in folds of the skin or wherever clothing can cause friction. Infections, such as staph infections that have spread, can also cause vesicular rashes. Contact dermatitis is an extremely common cause of vesicular rash.

Vesicular rashes may spread quickly. In the case of bacterial infections, keep the rash clean to prevent it from spreading to other parts of the body.

How are vesicles diagnosed?

You should always make an appointment with your doctor if you develop unexplained vesicles on your skin. During the visit, they’ll ask you about your recent health history and about any medical conditions that might be related to the vesicles.

They’ll also examine your skin. Your doctor may be able to diagnose the cause of your vesicles based on this information alone.

If your doctor is uncertain about a diagnosis, they may recommend more tests. They may also take a sample of fluid or a biopsy of the skin tissue from the vesicle to send to a lab. The analysis of the sample will help them to confirm a diagnosis.

How are vesicles treated?

You should always talk with your doctor about the best treatment options to reduce your symptoms.

Treatment for your vesicles depends on the cause. Over-the-counter (OTC) remedies may be enough to treat vesicles resulting from an allergic reaction, dermatitis, poison ivy, or cold sores. Many of these remedies are topical ointments that can soothe the skin. Antihistamines may be able to reduce allergy-related symptoms.

Vesicles can be accompanied by other serious symptoms, such as inflammation or infection. In these cases, your doctor may prescribe medications to treat the underlying causes.

For example, bullous pemphigoid — a type of autoimmune disorder that affects older adults — is typically treated with corticosteroids to help reduce inflammation and antibiotics to help prevent infection.

Bacterial infections are typically treated with oral antibiotics so as not to aggravate the vesicles.

Vesicles caused by eczema are often treated with topical medications, including retinoids and glucocorticoids.

Burn blisters or vesicles will be treated with prescription burn creams. You may also be prescribed oral antibiotics to reduce the chance of infection.

What home treatments are effective against vesicles?

Home treatments including alternative remedies can often be effective for treating vesicles or blisters.

To care for an open or torn vesicle, wash the area with soap and water. You can use OTC antibiotic ointment to prevent infection. Cover the area with a clean bandage to protect it.

Natural treatments for vesicles that haven’t been torn or drained include:

  • aloe vera, which is soothing and has anti-inflammatory properties
  • apple cider vinegar, which has anti-inflammatory and antibacterial properties to reduce swelling and help dry the vesicle out
  • tea tree oil, which has antibacterial and astringent properties

Popping a vesicle isn’t typically advised. This can leave the area open to infection and make it take longer to heal. Unless the vesicle becomes large and exceptionally painful, leaving it alone is best.

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